S&W 686-4 (4 inch bbl) and a Glock 19. That would cover just about everything I would use a handgun for (especially with super light 38 reloads). CCW, home defense, target shooting, and if I needed to, hunting.
My honorable mention would be a 22 lr, but I have never found a 22 pistol I really liked. So I would cheat and use an advantage arms conversion kit on the Glock 19.