I'm with BluesBear, as a production handgun cartridge, the S&W 500 rules (for now). This is not to say that someone, some where won't do something silly.
Ex: When I was working for a bank in Chicago, we had a young man in our dept who inherited a tidy sum from his grandma. He was driving a ratty Chevy Vega wagon and he was a drag racing fan. He managed to find a shop that would put a full-tilt supercharged L-88 427 with a B&M tranny into said Vega, with 'appropriate' running gear and a new paint job (blew alla granny's $$). He did OK on the street for the first weekend, but the first time he put it on the strip and pushed it hard, that motor twisted it up like a beer can, and he was back to riding the bus.
Just 'cause you can, doesn't mean you should - same goes for some 'wildcats' on a handgun frame (but it's your wrist/elbow/forehead).