Energy of a 22Mag from a handgun is somewhat akin to a 22LR from a rifle, yes. In barrels above 6", the advantage may go to the 22Mag.
MJRW: NAA's data stops at 4", but the trends are pretty clear:
The best loads are the 30grainers in handgun barrel lengths. And even then, the CCI +V is just head'n'shoulders past anything else.
OK, here's the NAA 4" barrel (MiniMaster) 22Mag velocity data:
http://www.naaminis.com/mmmagvel.html
Now granted, they only test one 50grain load and yours might be better but...the trends are REAL clear here.
Compare to the 2" data:
http://www.naaminis.com/bwmvel.html
You're going to get about 1,600fps from the CCI 30grainers from that Tracker barrel. That's gonna HURT, at 171ft/lbs energy. I recommend the "TNT" variant if you can find it, or the regular +V otherwise.
According to the energy table, you'll have to get 1,250fps from a 50grain to get as much energy. It seems highly unlikely you'll get anywhere close, but then again, you could always chrono it...your 50 might be a lot hotter than the one 50 NAA testedOOOps, no, just checked, they tested the Federal Classic 50. Federal's rating of "1650" is from a rifle, not a handgun - in my experience, and the NAA tables bear it out, Federal is "wimping out" on the powder charge or at a minimum, not tuning the charge for handguns at all.
If you are able to get 1,100fps or so, you'll get good penetration and it might be worth running 50s over the 30s, but I personally wouldn't. At 1,200, hmmm...tough choice, I'd pick based on accuracy, but ALL of these will be plenty accurate enough for home defense.