K frame size would be better IMO. Charter Arms Bulldog ( five shot .44spl, with a three inch barrel) had a neat idea with this gun, only for me and mine, the guns did not hold up to "our" use.
[We shoot what we carry)
.44spl is akin to 45 ACP, in being a low pressure round, and proven. So in my opinion, a "D" or "K" frame size, with a five shot cylinder, and three inch barrel would be better.
Still concealable, just the power to weight ratio would allow for better control for first shot hits, and quick effective follow up shots.
.44spl with speedloaders or quick/speed strips or 45ACP with the new polymer moon clips - either would work for me.
Steve