Thanks for the replies!
I definitely have some revolvers on my wish list. 44mag will probably be my next revolver, but for 10mm I think I'm going to go with an auto first.
I'm not familiar with the Witness, I'll have to check into it.
XDM is a possibility, I'm very happy with my XD .40. One pro of 10mm is being able to use my .40 dies, and the ammo if I need to.
I have heard before that Glock got the 10mm right , more so than others. I think Ohen Cepel is right. If I get a Glock , I'm probably better to get the longer barrel and frame of the 20.
I like striker fired auto's and 1911 styles for different purposes. I was thinking of metal 1911 style for weight to help with recoil. This gun will not see much use as an EDC. It might accompany me if I'm ever in bear country, but otherwise will be mostly for farm and home defense.
I also agree with WestKentucky and have mostly written off Colt for auto's and AR-15s. I do love the Python though.
I have a RIA .38 special that is not pretty, but perfectly functional. I had a RIA 1911 in 45 acp that I probably should have kept. I wasn't really unhappy with it. Someone else just wanted it more than me and 45 is not my favorite caliber anyway.
Thanks for the replies. They're all good food for thought.