In tthe Old Days...
....44-40 was not a popular handgun chambering, despite the theoretical advantage of being able to use the same round in your revolver and your carbine. As I understand it, the soft copper primer cups, combined with the slight taper of the case, led to several instances of primer backflow tying up the revolvers. While this should not be a problem with modern primers, the .44-40 is not a common round and, as I recall, if you load your own, you do well to get 45 rounds out of a box or bag of 50 cases as the case is prone to being damaged in the sizing process.
The most interesting passage I found in James Gillet's Six years with the Texas Rangers: 1875-1881 was the account of an earlier ranger who had inadvertently thumbed a .45 Colt round into the loading gate of his .44-40 Winchester carbine in the heat of a gunfight with a band of Comanche. The guy had the presence of mind to unscrew the side plate of the carbine with his knife, between handgun shots at the mounted Comanche. clear the jam, reassemble the carbine and get it back into the fight.