I laugh at these old notions. All handgun rounds are relatively weak stoppers. You can throw 9, 40, 45 all in the same basket. If you want real power bring a shotgun!
I disagree that "all" handgun rounds are weak. .44 magnum, .45 colt from a Ruger, .454 Casull, .480 Ruger, .500 linebaugh. .500 S&W magnum, .460 S&W magnum, 475 Linebaugh.....and then there are handguns chambered in .30-30, .45-70, .300 win mag, I even saw a revolver chambered in .600 nitro express!
I really like the .357 magnum over any .45ACP, though. It's a far better gun for medium game hunting, more power, more range. A 180 grain Hornady XTP at 1400 fps is packin' some PUNCH! Loaded with a 140 speer at 1340 fps, it's a damned fine self defense/carry choice, too, if you're man enough to handle all that recoil, flash, and blast. I do real well with it. Of course, I do have a Blackhawk in .45 Colt, might as well be called .45 MAGNUM Colt.
It's 300 grains moving at 1200 fps and it's a mild load for the caliber. I could go hotter, but don't figure I need to. Most of my deer hunting with handguns is done with a 12" .30-30, though, lowly 150 grain Sierra BT. It's only .308 inches in diameter, but it puts 'em down in their tracks with only lung shots. Go figure.