Ruger 10/22:
Great little inexpensive rifle that is cheap to feed and has tons of aftermarket parts capable of taking it from mild to wild. The stock target model I have is a tack driver capable of hitting .45 auto and 5.56 brass at 25 yards all day long.
Glock 21/30:
Large frames for big hands, brutally simplistic, and chambered in the venerable old .45 ACP. My first handgun was a G21c and it's never had any problems and is a dream to shoot. Had a few G20s over the years but I always find myself going back to the good 'ol G21 and G30.
Any decent quality 18" SXS coach gun:
I have a Stoeger but there are several choices here, look for something with exposed hammers which my Stoeger lacks and I might have to replace it for that reason. Still, there are few sensations that match that of lighting off two rounds of 12ga out of the two short side by side barrels. Can't shoot clays worth a damn, but it's still just good old fashioned fun.