From what I can tell, you are significantly below the starting charge, which can certainly cause some issues with primers backing out. I would also venture to guess your cases are pretty sooty, and possibly even pressure dented at the shoulders or wall. Use published start charges, they have been developed to produce minimum to maximum operating pressures.
As for mis-fires, it is possible for a sub level charge to have sporadic ignition problems, though I've never seen it happen. I would be more inclined to think that those primers aren't completely seated. Primers need to be seated at least .004" below the case head, or until you can feel the anvil preloading against the bottom of the pocket.
And it is also possible that the oal os too long, thus causing the bullets to rest up against the lands. When the firing pin strikes the primer the cartridge will move forward, which displaces the energy of the FP strike. And if the brass is not properly head spaced, the projectile will be creating a false head space, which can definitely cause mis-fires.
GS