No. I can be very close to “Yes,” but not quite there.
If printing unacceptably, with favored summer shirts, is a determining factor, all double-column-mag Glocks are out, and, a full-sized 1911, with a anything larger than a GI grip safety, is really pushing it. Larger-profile sights, which are better for my aging eyes, complicate concealment. I can conceal a full-length grip. Width, and rearward-protruding, squared-off slides, necessary to contain the striker mechanism, can require more than a shirt, for me feel that I am really concealing the weapon. I believe that there is a difference between casual concealment, the true concealment. When I carried a handgun, for official purposes, I could be casual about concealment. Since retiring from LEO-ing, I have already had one uncomfortable moment, when a manager, at a gun-free facility, was gazing at my right hip hip area. I quickly concluded my business, with what I hoped to be a confident poker face, and got outta there.
I no longer trust my aging right hand/arm/shoulder to always provide the most-stable platform, for reliable functioning of all autoloading pistols. Continuing to carry at my most-accustomed carry position, 0200-0300, means toting a revolver. I really do like my revolvers, so that is not a problem. Continuity of fire is an advantage offered by autoloaders, that use detachable magazines. Most defensive scenarios can be survived, with the amount of ammunition available in a revolver’s cylinder. Most. Yes, of course, continuity of fire can be achieved by carrying secondary and tertiary guns, but the original question was which handgun, not which handguns.
I do still have one of my older duty pistols, a SIG P229R DAK. The slide protrudes less, to the rear, than does a Glock slide, and the slide is more rounded at the edges and corners. The hammer is spurless. Even though it is a wide-body pistol, I can conceal it, to my satisfaction, under a shirt. I used to have non-railed P229 DAK pistols, which I regularly toted concealed, during personal time. My only concealment holster, to fit this P229R, however, is right-handed, and, I know that I can numb-thumb/limp-wrist a malfunction with it, if my aging right hand is having a bad day. Plus, after I retired this this weapon, from street duty, my non-railed SIGs were sold-off, and several of my magazines, and virtually all of my .40 ammo, were re-homed, with LE colleagues, as I transitioned to 9mm Glocks for duty, and much personal carry. I recently found enough properly-stored .40 Gold Dots to load one P229 magazine. I also recently managed to find, and order, my three-box limit of fresh .40 S&W ammo from Midway USA. This simply restores this weapon’s status as a left-handed home-defense weapon. If I obtain a lefty holster, that nicely rounded-off slide is not the easiest thing for my gimpy right hand to grasp. So, this pistol does not enable me to reply with a “yes,” to the question posed in the original post.
An optic mount, with a closed-emitter optic, and iron sights, together, on one reasonably concealable weapon, with detachable-magazine reloading, for continuity of fire, is achieved, for now, with an autoloading handgun that I own, but am not (yet) carrying, as the panic-demic interrupted my vetting of this combo. The accessory rail accommodates a Surefire X300U. The optic can serve as an extended slide racker, in case my aging right hand, particularly my right thumb, is having a bad day. (Remember the part about my not trusting my right hand to provide a stable platform, for reliable autoloader functioning.) This could be the one handgun that I have, that provides me with the most options, for the greatest number of foreseeable defensive scenarios. It is a Glock G19x, with a custom-milled G45 slide, with an Aimpoint ACRO P-1, and iron sights. Obviously, I won’t be truly hiding this, successfully, under a “favored summer shirt,” or even under my favored sport coat. This one may well become more of a “bag gun,” or situational “dress-around-it” gun.
So, back to the original question. I do, normally, carry a revolver, with a grip long enough to firmly reach the “heel bone” of my weapon hand. Long-stroke DA is my least-perishable trigger skill, and my most-highly-developed handgunning skill. My revolvers point very well, in my hands, so even if the conditions do not favor my aging eyes, I will probably be OK. I could have answered “Yes,” and not been lying. Continuity of fires does favor autos, of course, so, it would have been a conditional “Yes.”