The standard round for 300 AAC BLACKOUT is 123 grain and duplicates the 7.62x39 ballistics - which is by far the most successful assault rifle cartride of all time. And outside of combat, for LE and self defense, it has more energy than 5.56mm at the most common shooting ranges.
What about over-penetration? One of the reason the 5.56 has supplanted the 9mm carbine for LE use is that the latter (9mm) has more penetration in urban environments typical of LE operations. The same would be true of HD use. I don't want a round flying through several wall and killing the neighbor down the block.
And as far as military actions, we know from experience that ball 7.62x39 is actually not so lethal compared with 5.56x45 ball. The former's 'success' was certainly helped by the reliability of the rifle that fired it, as well as the fact the now defunct Soviet Union gave away train car loads of rifles and ammunition.
I can see a role for this cartridge, but I don't think it is the panacea some do. Yes, it may have Remington's backing, but so did rounds like the 260. The 6.8 is now a legitimate cartridge, but compared to the 5.56, it is a niche round.
As long as we are limited to the mag length of the M16, and the same bolt thrust/working pressure, we are only trading weight and velocity.
I've killed deer with 5.56 and 6.8 and frankly, I couldn't see any difference. Put the shot in the vital area, and it goes down.
The principle concern I have is that Remington will support this for a short time, and if it doesn't sell enough, it will go to the back burner. Then you have a limited source of commercial loadings, and you'll have to handload to get any decent bullet selections.
Something like the 6.5 grendel.
BTW, what are the exact differences between this round that the 30 Remington AR? Another new AR round that was supposed to have the backing of Remington.