I practice with my carry ammo as regularly as I can afford to, but all in all I end up shooting a lot more FMJ 'range' ammo when I have myself a shootin' day. This leads to chambering and un-chambering the defense ammo from time to time. So all that being said, I used to deal with bullet-setback after chambering the same round more than a few times... Until I picked up an interesting tip either here or another forum.
I'm not sure why this works exactly, but for some reason it works for me. I honestly actually haven't had any bullet setback since I began this practice, and I compare and check rounds every time too: For defense-ammo that you may very well load and unload again many more times in your future, when chambering the first round, do so from an otherwise empty mag. As in the first/chambered round is the only round in that magazine. Then load the magazine, or swap empty mag for an already full mag. I'm guessing it has something to do with the amount of magazine-spring tension pushing upwards, but I honestly don't know exactly why this works. All I know is since I first started trying this I haven't had anymore bullet-setback in my defense ammo.
Give it a try and let me know if it doesn't work for you, I'm very curious.
My experience with what I just described has been used primarily on my S&W 1911, Armscor 1911 (both in .45acp), and S&W 5906 so far, for just shy of a year, so I can't testify as to how this will work for other semi-autos.