I have been doing research with the .410 for well over a year now (In long gun and I have began working with the handgun)
That is how I have seen it's strengths and it's weaknesses.
And all things being equal,it's why I'm glad I made the choice,I'm not saying that others have to make the same choice.
But if a person is looking for a one shot fight stopper at normal defensive use ranges in a handgun then a 410 revolver loaded with '000' buck is a very good bet.
Also I wouldn't risk using the PDX-1 410 in a handgun (recoil is way too stout and down range performance is not what I would write home about)
Which is why I've stayed with the '000' buck load from federal.
Better recoil control and firepower at close range.
Also here is a vid some might want to look at....
http://www.youtube.com/watch?v=2_iJ34EHuQs