While not optimal, I recall Mas Ayoob mentioned that some old folks with limited hand strength for semis could manipulate a single action revolver. Before one spouts cliches, this falls in the category of better than having nothing or something not usable. The Ruger Bearcat or if the weight isn't too much, the Single Seven in 327 magnum. The former can have some high speed loads and some of the specialized 22 LR SD loads like Punch. The latter can handle very mild 32 SW Longs, and 32 HR magnums which are not trivial.
Just a thought.