Women, guns, first time shooters/CCW.....
First, Id suggest your wife shoot a few rental guns or gun club guns(some places only allow private owned firearms due to legal-civil liability issues).
See what models or types she can safely load/unload/fire/field-strip/etc.
Some women lack the hand strength to shoot a semi auto pistol/work the slide.
If she can properly handle a compact or sub-compact pistol, there are a few good CCW choices she could get; a Beretta Nano, the SIG Sauer P290RS, the Walther PPS, the SIG P239 DAK(spurless DA only), the S&W M&P Shield, the XDs, the Kahr CM9.
A DA only model would be better & safer than a SAO(single action only) format. A light trigger or a complex manual of arms isn't ideal for a entry level gun owner(male or female). Keep in mind too, in a real critical incident, she may be hurt, have stress or chaos, be in a low light/night area, etc.
A well made, safe format like the M&P Shield or the P290RS would work. They have been in the US gun industry for a few years & sell a lot to CCW license holders.
A "witness" or PR seeking lawyer couldn't claim she "cocked the hammer" or was careless. This is why a lot of sworn LE agencies mandate DA only weapons.
Teach her how to properly clean & lube the firearm too. She should be aware of how to clear any jams or fix minor problems. Id advise she only use factory made high-quality 9x19mm rounds. No reloads or hand-loads for carry. Brands like Corbon DPX, Hornady Critical Defense or Critical Duty, Speer Gold Dot, Federal HST, PowRball, etc.
Make sure she learns & understands the gun/use of force laws too. To have a family lawyer or legal defense plan is a smart idea for you both, if you have not already.
Rusty