Ruger quality control of late has been good.
If you have smaller hands, try gripping a Ruger SP101. Not that that's the gun you want, but a smaller GP100 grip similar in size to the SP101 grip is available for the GP100. The GP100s with fixed sights come with that smaller grip type - it's similar in size to the SP101 grip but not compatible with the SP101.
This smaller grip will set you back about $40 all told - Lett Grips should have them in stock, or order from Ruger or Brownell's. Many people love the big fixed-sight GP100s with that smaller grip on there. You can't get a grip that tight and compact on an S&W due to the grip frame shape.
Ruger used to sell GP100s with a "short lug" barrel. You can still find 'em used. For example...errr...dang, both gunsamerica and gunbroker are completely dry of same. Looks like they've been snatched up! Anyways, they point like the finger of God...overall "heft" is similar to a 4" full lug GP100 'cept it's a 6". GREAT gun. If you like "muzzle light" fast-pointing critters consider either finding one or having any local gunsmith or machine shop chop most of the lug off a standard 6" GP100. It's pretty simple, just cut away the lug starting just after the tip of the ejector rod.
One more thing: DA Rugers can be field-stripped without tools, other than a single standard screwdriver for the grip panels. Once the grip is off you'll find a takedown tool hidden under one of the panels. It's really neat. This is a MAJOR advantage in really rough conditions. If the gun ever takes a dunking in saltwater, mud, whatever, you can field-strip it by the campfire...it makes the Ruger DA series a big cut above in a wilderness survival piece.
That said: Ruger does produce real lemons once in a while and "cosmetically challenged good shooters" somewhat more often. I recommend "the checkout" on ANY new or used revolver this side of a Korth or Freedom Arms and would not buy a Ruger sight unseen unless I really trusted the seller.
But then again, I'm *very* picky about my guns as I own and buy very few and need to trust them all.