As much as I like S&W revolvers of this time period, I do not have N-Frame-sized hands. If I am going to be shooting double-action, I have to use an improperly-centered hold. I wrecked my right hand, doing just that, in the Eighties, with .44 and .41 Magnum N-Frames. By about 1990, I knew better, having learned about ergonomics and kinesiology, and so then used K-Frame and GP100 revolvers, and single-stack autos. (I have long, deep palms, so like the feel of N-Frames, but my fingers cannot adequately reach the center of the face of an N-Frame trigger, in DA mode, especially the wider triggers.) So, my answer, between the OP’s two choices, would be the 4506-1.
I did own S&W Models 3913 and 3953 pistols, in the Nineties. They went away, by the time I started a mostly-1911 phase in 1997, but, a couple of years ago, during a nostalgic time, I acquired a well-preserved railed S&W 3913 TSW, and then a Model 908. After my second Covid vaccine shot, hopefully later this month, has had enough time to be deemed effective, I can start visiting a shooting range again, so will then start shooting these. (I have one underlying health concern, and my wife has several, so, going to shooting ranges has had to be suspended, for over a year, by now.)