Currently, I keep my Glock 19 with Trijicons near the bed in a Wilderness Tactical SafePacker, along with a Surefire G2 (65 Lumens).
I've had this pistol for about 3 years; it has digested many thousands of rounds and has proved 100% reliable with non-defective ammo. It's loaded with 15+1 rounds of Proload 124gr +P (Gold Dot), with a spare mag of 17.
'Course, as I get spoiled by my single-action semi-autos (BHP, CZ), I may change this choice in the future...
-z