In general, my perfect fightin' sixgun would be a 4" to 6" Ruger GP100 or S&W L-frame. I shoot these better than any other handgun, period. Specifically, my two older GP100 sixguns have grunge grooves under the extractor, to give somewhere for fouling to settle, if anything gets in there during a reload. To get even more specific, my first GP100, purchased around '91 or so; it is 4", fully lugged, with adjustable sights. Lots of felons have looked up its barrel, and one of them went to the morgue.
I like bigger bores, but my large hands are matched up with medium and small fingers. An N-frame or Redhawk is just too big for me to handle well in DA fire. My bigger bores are either autopistols or single-action sixguns. This same factor keeps me from taking advantage of the 8-shot S&W .357 revolvers.