Everyon's favorite will be somewhat different because of the different uses and needs if individuals.
I really don't plan on shooting anyone however I felt the need for a powerful trail companion and a reveolve that could be applied to a "social Situation" if need be.
I opted for a 4 3/4" Ruger Vaquero .357. WHy? Well All my life I have owned and shot single Actions and the operation is second nature over D/a or a Semi Auto Pistol with it's many movements. The Da's that I own are .38 Specials and I find them very comforting if you know what I mean...
The Vaquero rides in different leather at different times, A Western Style 1880's SHolder rig based on an old Texas style, a high ride hip holster, strong side with modern snaps to contain it, and last a 1880's Pancake, socket style, Crossdraw. When I ordered it the little write-up said it was copied from an Arizona rig of the era.
They all have a purpose but I gotta admit the Crossdraw is most comfortable and versitile. The SHolder rig makes the pretty big Ruger invisable under a coat.
The hip holster is great for walks and sitting at my portable shooting bench. I often carry a powerful revolver while airgunning since running into a large pack of Hogs and a BIG trio of Farm Dogs that snuck up beind me. No problems, just you need to have something when out alone in the fields etc.
I know that different answers will abound in this string, this was just mine.
BPDave