I don't own a lot of big bore handguns. I have a 4" Model 29, a 3" 629, a Ruger Blackhawk in .45 Colt, and a Super Blackhawk.
I would have to say my faviorite is the 7 1/2" Super Blackhawk. It is kind of a pain to carry on the belt, although I did so for several years when traveling off the beaten path. But it is a very strong gun, and mine is very accurate. It is just one of those guns that is a real pleasure to shoot for me. I don't think you can really describe how some guns just seem to be the perfect thing for you.