Primary is a relative term, meaning different things in different contexts. I have one of my SP101 .357 snubbies with me virtually all the time, but the snub is not always the largest weapon at hand, nor the one I would prefer to use in a fight. I wear a badge issued by an agency that has us buy our own duty pistols, which must be certain double-action autos chambered in .40 S&W. My current choice is the SIG P229 with the DAK trigger system, so at work, and much of the time when not at work, I would be reaching for a P229 rather than the snubby in most scenarios.
Both on and off the job, I may have one of my longer-barreled .357 sixguns with me, and at longer range, I shoot such weapons better than the snub or the P229. A few bad guys have looked up the barrel of one of my GP100 sixguns, while the duty auto remained in the duty holster, especially when my duty auto was a Glock. (I sold the Glocks after making the switch to SIGs, as I was never able to shoot a Glock as well as a 1911, sixgun, or SIG.)
So, any of these weapons could be "primary" at a given moment in time. Notably, all of these weapons point well for me; there is no need for me to switch operational modes; just point weapon and start stroking a DA trigger.
The wild card is a Les Baer Thunder Ranch Special, which I still shoot on occasion, and can shoot accurately, but with its different trigger system, I no longer carry it where it will be the normal "go-to" weapon in a grab-and-shoot situation. For a while I was an all-1911 guy, and those days could return after I retire.