I own handguns in .22lr, 9mm and 38 Special. The 22 is a target gun, the 9mm my CCW, and the 38 is my wife's defense piece.
I own rifles in 22lr, 9mm, .223, .7.62x39, and .308. The 22 is for practice and plinking, the 9mm is a truck gun, the 7.62 and .223s give me weapons in those common calibers and one of the .223s is my wife's combat weapon, the .308 is my primary arm.
John