Why 45 ACP?
Okay, below are MY answers:
I reload. The 45 ACP and 30-06 cartridges I reload for use the same shell holder, which is convenient. Handling 45 ACP cases is easier than 9mm, akin to Duplo vs Lego. The 45 ACP has a very generous safety margin for reloading, because it's not high pressure and by virtue of being bigger, a variation of 0.2 grains of powder is less critical in 45 ACP versus 9mm. Additionally, the 45 ACP still works well, hits effectively and cycles reliably even if I'm not loading for max velocity. Historically, savings were greater reloading 45 ACP versus 9mm.
Performance wise, old mountain men & cowboys killed everything big enough to die on this continent with 45 caliber lead projectiles. It's not ideal, ya, but I've never seen a sane person argue the 9mm is better than 45 ACP on any carnivorous wild animal.
Perhaps under ideal circumstances, with careful scientific method and advanced engineering, a 9mm can perform as well as 45 ACP. Fantastic. However, the 45 ACP is generally considered a superior performer to 9mm to some degree, either minimally or moderately.
The fact, and it is a fact, that you can stuff a lot more 9mms than 45 ACP into the magazine of a given handgun platform is a counter argument used in favor of 9mm. This becomes a personal decision. In a defensive shooting, would I rather have the first 8, 9 or 13, etc rounds be a little more effective, OR would I prefer a few more rounds of a lesser effective round? Personally, I'm more concerned with rounds 1,2, and 3 than I am rounds 15, 16, and 17. Each additional moment my attacker can continue his assault presents a significant danger to me. It's a crap shoot, but if I have to gamble then I'll gamble on the marginally better performing first few rounds before I gamble on needing rounds 17, 18 or 19 without a reload, and still being around to use rounds 17, 18, and 19 when I get that far in. At the close ranges most studies suggest deadly encounters occur at, if the 45 ACP can stop the aggressor one step sooner, then I'll bank on needing that more often than the 19th round in a mag.
I've googled it, and while various studies don't always agree in the average number of shots fired in a gun fight (2, 3, etc.), I've never seen a study where the average rounds fired in a defensive shooting exceeded the capacity of a traditional 1911 magazine.
If a platoon of ninjas bent on blood lust is still pressing the attack after you've dumped a half-dozen aimed rounds into the leaders, then you've got bigger problems than a double-stack mag can fix.
For the lighter weight 9mm vs 45 ACP argument, see above. The "load-out" required for a civilian self defense pistol isn't substantial enough to merit the weight of the cartridges a factor. If you're able-bodied enough to work the handgun, then you can carry enough rounds or 45 ACP to defend against any realistic threat.
Which brings us to the "follow-up shots" argument. The 9mms are faster to shoot because they recoil less. Well that's good, because if they are felt less by the sender than they are felt less by the recipient, so the 9mm shooter is more likely to need follow up shots.
Well, 9mm is still more accurate because the lower recoil causes me to flinch less. Well, that's a training issue, number one. Additionally, I can handload my 45 ACPs to shoot very soft. I can optimize them for exactly what I want.
So for me, based on my logic, needs, and abilities, I choose 45 ACP for my sidearms.
I use 9mm for ankle carry, which is where I think it really shines.