I have and had handguns with and without manual safeties.
The only handguns I have ever owned that "need" a manual safety are C&L SAs, be they 1911A1s or CZ-75s.
I perpetually find the Glocksters amusing. "IT" (being a negligent discharge) CAN'T HAPPEN TO ME. It's just a variation on the dumbass DEA agent who shot himself on film proclaiming his own professionalism ahead of the unexpected BANG. Of course there is no phenomenon called "Revolver Leg" or "Sig Leg," only "Glock Leg."
The common denominator in handguns without "active manual safeties" is that they have something else that mitigates against an unintentional pull on a short trigger travel. Only the Glock series defies this convention wholly, hence "Glock Leg," and Glock's "NY Trigger." Hmmm. NYC has a hardware solution for a problem that doesn't exist? Maybe, but in this case, training has not proven adequate over the past twenty years to shake the Glock of its ND waiting to happen image.
A Sig-Sauer traditionally has a long first trigger pull, usually in double digit poundage. More recently, they and other manual safety-less makers have gone to a "constant pull" solution that is lighter than the old DA pull, but still has a relatively long travel compared to the old SA mode, which no longer exists in CA or DAO weapons.
Of course, revolvers did and still rely on a much longer and, in stock form, a heavier trigger pull than does a partially cocked Glock. Finger off of the trigger is great, but if the finger, or the unwanted finger of a BG, or foreign object, is on the trigger, about 5.5 pounds or less coupled with a short trigger travel hasn't proven itself to be much margin for safety. People get complacent, so I begin to wonder if, as designed for the military, the Glock too wasn't intended to be carried in Condition 3, just like Uncle Sam's dangerous 1911A1 was to be carried outside of imminent action.
There is nothing "luddite" about that. I scarcely doubt many would volunteer to carry a C&L Series 80 1911A1 with the grip safety pinned and the thumb safety off. Well, why not, if you keep your finger off the trigger? My feeling is that no one could be long comfortable being millimeters from an instant BANG with such a rig, even with a firing pin safety. Yet the Glock just gives one some more millimeters of trigger travel as a margin before the striker engages the primer.
A Glock reminds me of strapping on a fixed blade knife with only a frog as its carry method. Yes, if careful, the blade wouldn't slice you, but the moment you brainfart, or get complacent, it's time for a trip to the ER for stitches because you one day may find the naked tip penetrating deep into your leg.
The XD gets around the problem with a passive grip safety. No "XD leg" yet I have heard of, though I suppose it is still entirely possible given that reholstering could trip the grip safety.
Most pistols without manually activated safeties don't need them. Revolvers don't need them. Glocks arguably do, for the masses. If that weren't at least plausibly true, the Cominolli safety wouldn't be a factory approved Glock modification.