There are a lot of mechanisms of death in penetrating trauma that do not involve penetrating or perforating injuries of the upper CNS or hypovolemia due to blood loss. And there are non-lethal mechanisms of injury that may take an assailant out of the fight quickly or temporarily. Some of these are immediate and some are rapid.
A few examples: Gunshot wounds to the head that do not penetrate the skull will often cause unconsciousness. It is possible for penetrating trauma to cause upper airway obstruction either directly due to deformity of the trachea or larynx, or by flooding the airway with blood. Most individuals with upper airway obstruction will stop the fight immediately (remember the soldier who got shot in the neck in "Saving Private Ryan"?). Penetrating injuries of the chest can cause pericardial (cardiac) tamponade or tension pneumothorax in the absence of physiologically significant blood loss. With pericardial tamponade loss of less than 100 cc of blood into the pericardial sac can effectively disrupt cardiac function. With tension pneumothorax entry of air into the pleural space (chest cavity) either due to leak from perforated lung tissue, or a sucking chest wound, compresses and kinks the vena cava interrupting the return of blood to the heart. It is even possible in rare instances for non-perforating injuries of the chest to cause immediate cessation of normal cardiac electrical activity and sudden cardiac death (commotio cordis).
Other non-fatal mechanisms of injury that can immediately incapacitate an attacker include injury of major nerve trunks or branches going to the dominant upper extremity, wounds that fracture bones of the dominant upper extremity, or wounds that fracture weight bearing bones and joints of the lower extremity. A facial wound that effectively blinds the attacker will quickly take them out of the fight. And there are superficial arteries outside of the chest or abdomen that can be disrupted causing rapid and massive external bleeding such as the femoral, popliteal, and carotid.
None of these mechanisms of injury can be predicted or guaranteed, and not all are immediate. But it isn't always about hitting the CNS or blood loss.