As Ruger is now producing two reliable, double-action revolvers at a fair price (the LCR and the SP101), I'd choose between those. If you're a revolver shooter, this'd give you a great practice pistol that
could be carried if circumstances required. Both have 8-round cylinders. The LCR's about 15 ounces, and the SP101 is double that. Neither would be a problem to carry, although the SP101 is a belt gun, not a pocket gun.
I would, of course put at least 1,000 to 2,000 rounds through any .22 revolver ASAP, to make sure it was reliable and to verify its favorite ammo. I have found, for example, that Federal HVHP would not ignite every time in a youth rifle we have (hammer strike was too light), while the gun was 100% with Federal's "AutoMatch" .22LR ammo. Ruger has a good reputation for both a good product and good service, but it pays to be sure.
Injury or other issues could strike anyone, so a light-recoiling handgun isn't a bad idea. There are other ways to go, however. I concur with the previous posts favoring target wadcutters in an all-steel S&W K-frame or (my choice) in a Ruger SP101 or GP100. This last one, with a four-inch barrel, is very gentle with target ammo. The only problem is finding .38 wadcutters on a dealer's shelf. You'd have to order your carry ammo, in all likelihood.
OTOH, practice ammo is a cake walk to make! There is probably no easier cartridge to reload, and wadcutter loads are very simple to put together. I've fired thousands of my own (cast from a Lee mould and lubed in a plastic bag with Lee Liquid Alox). Wadcutters are pleasant to shoot, accurate and much more effective than you might expect. Here's CE Harris' take on wadcutters for serious use:
And now for something completely different:
For an unusual low-recoil pistol, you could go with a Makarov .380 with a threaded barrel -- not for a suppressor, per se, but for extra weight. Imagine a long flash hider, bored out for the .380 (actually .355, IIRC) bullet. It wouldn't affect cycling in a blowback pistol, but it would give the
Pistolet Makarova a "Man from U.N.C.L.E." kind of look. Mak's are very reliable, and I know from experience that you can make light handloads and still have 100% function. The gun's about 26 ounces, and all the added weight would be where it could do the most good. This would make practice a breeze.
Not a practical pistol, but it could be fun.
All my best,
Dirty Bob