Most "experts" recommend the .25acp over any .22 rimfire round because of the more reliable centerfire primer of the .25acp cartridge.
I once had a .22 caliber Beretta Minx that often misfired when using most brands of .22 ammo, especially CCI. I tried several other brands and the only one that would fire reliably without fail was Remington. I believe that was possibly because the Remington brass may be softer than the others, or maybe the Remington priming mixture is more sensitive to a light hammer strike than the others. The little Beretta's hammer spring was noticeably weak compared to a full or medium size semiauto spring.
Whatever the cause, I decided it was impractical to keep a pistol that would only fire reliably with one brand of ammo. So I sold it at a loss and advised the buyer to use only Remington ammo if he intended to use it for a defense weapon. He already owned a little-biddy North American Arms single action .22 magnum revolver that he used as his regular carry gun. I assume he wanted the semiauto Beretta because of it's much faster rate of fire compared to a single action revolver. However, I seriously question the wisdom of using any .22 handgun as a first line defensive weapon unless that's all the owner can afford, and in that case any gun is far better than no gun.