If you want a simpler manual of arms--get a double action revolver and it has no safety to disengage and can be handled quite securely with a round in the chamber.
Otherwise, as the folks above have mentioned, practice is necessary to know the manual of arms for your particular pistol. If you are worried about carrying one in the chamber of a semi-auto, then I would suggest looking at the XD which has a grip safety as well as trigger safety. As noted above, Israeli's used a bunch of different weapons and then settled on a clone of the High Power for awhile. Under the best conditions, the High Power is like the 1911, best carried as cocked with a round in the chamber and locked with the safety. This takes a while to learn to do so reliably on the drawstroke. Thus, for reservists and other lightly trained personnel that deal with weapons qualification, both the U.S. and Israelis came to a similar conclusion. Carry the chamber empty and rack the slide when necessary to fire with no safety on (aka U.S. Military condition 3). This also avoided the possibility accidental discharges if the firearm was carried cocked and locked as the 1911 as issued was not absolutely drop safe (don't remember about the High Power but I think the older designs did not have a firing pin block either).
As far as grips go, first, find a firearm that fits your hand. Your grip will be unnatural if the trigger distance is too far or too close. You can learn to adapt but better to first have a pistol that fits your hand as you will always be more efficient with that firearm. Some firearms have the happy design characteristic that they fit most hands which is why some of them stuck around for so long--e.g. the K frame Smith and Wesson revolver, the 1911, and the Browning High Power are some examples. Newer semi-autos with user changeable backstraps also have changed the game so get what fits first. Then develop your master grip--it will be different if you fire both revolvers and semi-autos versus semi-autos only.
The whole ninja instinctive point shooting thing is overblown and it ain't new. Read Fairburn and Sykes and Rex Applegate, or Bill Jordan, and you will come to an appreciation of why it was adopted by the Shanghai police, the OSS, or simply as a trick to shoot aspirins off a vehicle bumper.
It is simply using a different index (point shooting methods differ) to determine where the bullets should go and as you get away from using the sights, you would expect and get more error. At bad breath distance, this error is of lesser consequence--at longer distances, it can cause you to shoot something or someone that you shouldn't.
Bill Jordan in his book, No Second Place Winner, stated that he was accurate enough to shoot aspirins off a bumper by body indexing at a KNOWN distance and by expending a lot of ammunition through practice to get that good. He was also by all accounts a very gifted and experienced marksman. If Bill Jordan said that it wasn't worth the time and practice to get that good using a body index (hip shooting if I remember) that worked only at a known distance, then I don't really consider it that viable as a GENERAL shooting technique. Mas Ayoob in his combat handgunnery volume, talked with Rex Applegate and got him (has a picture of it) to demonstrate his point shooting technique which was to raise the firearm to eye level so you could see where the firearm was in relation to the target. I believe that Mas came up with the term "flash" sight picture at close range where you bring the pistol up to eye level, confirm the front sight is on target and then fire. If I recall, maybe Jim Cirrilo but really don't remember, came up with having people shoot with no sights but raising the firearm to eye level and becoming familiar with using the slide top itself and consistent presentation to index the firearm and shoot with acceptable accuracy at typical self-defense distances. I am acquainted with Pincus and his views but honestly don't remember much that he proposed was much different than above.