I tend to use Gold Dots lately, due to availability in quantity. I could get .40 180-grain Gold Dots when I was reliability-testing some new P229 duty pistols, during the Obamascare, by shopping at a couple of local law enforcement distributors. (Local taxpayers are very tight; I have to buy my own firearms and ammo.)
Even though it is scarce, I have recently adopted the Gold Dot Short Barrel load in .357 Magnum for my SP101 and S&W Model 19 revolvers. My wrists are not so tough anymore. In my heavier-weight GP100 revolvers, I will still use the full-pressure loads, preferring Federal 125-grain JHPs when I could get them, but lately, it seems local stores stock equivalent full-pressure Gold Dots, so I now use them. I used .357 Winchester Silvertips for a while in my lighter-weight .357 recolvers, but its price went way up, and local dealers stopped stocking it.
I have just about used up all of my cache of .45 ACP 230-grain Hydra-Shoks, which I used for many years, and as I have recently started carrying my TRS some of the time, again, I will need to run through a couple of hundred of some new load to establish reliability and confidence. (My TRS has never malfed, but it is good to be sure.) It seems .45 ACP Gold Dots are not so common locally, so I may settle upon something else.
This covers the defensive handguns I tote the majority of the time, when humans are the perceived threat. I prefer the heavier bullets in the auto-pistols, but lighter in the .357 revolvers. If larger critters are in the mix, I adjust the .357 ammo accordingly.