About the only rifle-caliber that is suitable for Home Defense is hollow point or soft-point .223 (hollow point being the preference).
Untrue. Any rifle with rapidly expanding bullets is probably just fine for home defense.
You do want to choose a platform that doesn't have too long a barrel, and that is light enough for you to use rapidly. It may not be necessary, but quick follow-up shots would be a plus, too.
Also, tests in gelatin have shown that full-power Foster slugs penetrate less than other effective defensive shotgun choices (17" in gelatin, which will equate to even less in actual tissue). Full power slugs are a fine choice, as long as you hit your target...but that's true of any firearm.
Good choices for HD rifles:
Any lever-action rifle with no more than 20" barrel, in any caliber from .357 Magnum up to about .300 WinMag (Be certain to use rapidly expanding rounds for powerful calibers- IOW, don't choose 180-grain bullets for .300 WM.);
Slide-action rifles with no more than 20" barrels, in any caliber larger than .22 Magnum;
Semi-automatic rifles with no more than 20" barrel, in any caliber larger than .22 Magnum;
Bolt-action rifles
if you can rapidly manipulate them.
In general, pistol caliber carbines are poor choices. Pistol ammunition tends to be overly penetrative, unlike
lightweight, high speed, fragile rifle ammunition, which will tend to explosively expand or fragment at very close range, and which is considerably more powerful than pistol ammunition. The down side will be more blast.
Wear electronic ear muffs if you have time.
John