I shoot for the shoulder, but then, I don't use toys I got out of a Cracker Jack box. I won't go with anything less than .243 Winchester. My .257 Roberts has plenty for shoulder shots and any meat damage is minimal and just chili meat/sausage meat/jerky meat anyway, not the good stuff. I don't find that my .308 does much meat damage, either, totally acceptable. The 7mm Rem Mag, well, I don't use it much, pretty nasty. Lately, I've gone to using a CVA Wolf in 50 caliber and stuff it with a 385 grain Hornady Great Plains Minie ball. You can eat right up to the hole. It doesn't kill by shock so much as it takes out large chunks of blood laden tissue and breaks bones on the way. A deer can't go far with his shoulders taken out. They're not bipedal.