.22LR (small game, vermin, plinking, etc.)
.357magnum (larger game, long-range shooting)
.45 ACP (get YOU out of my face/EDC~!)
5.56mm (something every gun owner needs)
12 ga shotty (home D'fense, especially answering a knock at the door after nightfall,
and as a "bedside betsy" for "a thump in the night"; along with #3 above~!