Modifying factory ammo to fit a gun only marginally smaller than the gun the unmodified ammo would fit in
Huh? What's the point? The only thing the SSS has going for it is the big heavy bullet and low report, you're going to lighten and mangle the bullet and run it in the most noisy gun for size I know of ... do you have a big crate of SSS to use up, or something?
I think we have someone enamored of two extremes, with no concept of "the point of diminishing returns" when it comes to overspecialized guns or ammo.
The NAA .22short is not really much smaller than the .22lr model, it is a curiosity or a toy more than anything. And for that matter the .22mag frame isn't much bigger, either, although .22WMR is mostly louder, not faster, in that gun. (fun though, sort of a "noisy cricket" effect)
SSS ammo is spiffy and good in rifles for accurate, quiet shooting (not always available together) at moderate ranges ... it isn't a death ray and it isn't formulated to go in little bitty revolvers with large cylinder gaps. That being said, I do have a .22WMR/lr convertible NAA mini, and I'll try to remember to take it, the LR cylinder, and a box of SSS to the range next time.
Now, as far as cylinder strength, I'd assume it would be just as strong as the LR cylinder, but shorter. I'd also assume that a mangled SSS bullet might hang up and increase chamber pressures, making predictable/repeatable pressures hard to quantify. And I'd also guess that the nice folks at NAA would laugh at you for days around the coffeepot if you called and asked about your "chopped SSS in a NAA .22s gun" plan.