Apples to handgrenades
OK as you are entertaining thoughts of using the five-seven in a defensive role and using varment grenades on the wrong type of vermin and at ranges that truely render the weapon useless. I have something for you to chew on.
I'm not going to compare it to a rifle or rifle round.... nope to easy; all modern military rifle rounds make 5.7x28 a joke at all ranges and under any circumstances.
As a SMG I would say that the added range gives it an edge as a "compact rifle stand in" that would possibly be better than a SMG in certain circumstances as a last resort weapon when someone finds themself dropped into combat unpepaired (pilot's best friend potential for sure) so im going to give it a possible legitamate use there. But I would go as far as to say that when a SMG is taken into battle intentionally it is meant to be used at pistol ranges or a little further and virtually all realistic pistol ammunition used in SMG's would get that job done better (kill the creep faster at close range).
Armor penetration: Sure if you are millitary or law enforcement... You and I can't get that ammo and the millitary and police have better toys. Kind of useless there, too.
Lastly, a pistol comparison. You and I are not likely to run up against body armor, so lets change armor penetration to penetration for this. That's actually a factor according to the FBI, where AP is not.
You like a Pistol with 20+1 capasity.
You like a pistol with long range accuracy.
You like a pistol with flat trajectory.
You like a polymer lower.
You like 10mm.
This is not the gun you seek. this is a plinker or conversation piece, at best.
What you are dieing to get your hands on is a Glock 20 with Ardondo +5 base plate.
20+1 ~ check
long range and flat trajectory ~ check
Polymer ~ check
10mm ~ check
Way better penetration ~ Check
Rapid target reaquasition ~ not as well but each shot delivers 3x the ME, at least, so you wont have to shoot them 20+1 times and then pray like you will with the 5.7
AP ~ probably not, but they will wish it had.
I mean honestly it is having to use special law enforcement/military, illegal to the public loads to almost be as good as a low end 9mm, which itself with the police only +P++ loads is almost as good as a real side arm.
If it's not fair to kick the five-seven's butt with a glock 20 compairison I will let YOU compair it to a Grendal P30 with 30+1 rounds of .22 magnum just to add insult to injury if .22's are your thing (also no good as a combat weapon).
I give it the rating ***better than a knife***
Have fun thinking and rethinking your .22 to try and find some real use in combat and back to the 10ring with uncle Ted I go.