The whole problem with all these type of threads is that it doesn't and can't take into account one of the variables that we can't control. The person being shot. Each shooting is a unique event. The things a bullet should do are well documented by the F.B.I.. A bullet must penetrate deep enough to disrupt vital organs (brain, heart, major arteries and blood vessels...) no matter what the angle it is fired at, it should expand to give the highest possible wound volume, and so on. The shooter must of course do his/her part and place the bullets well and repeat as necessary.
But is the person highly motivated, drugged/drunk, thin/heavy, muscled/fat, and so on? In the book "Thank God I had a Gun" one of the chapters deals with a man who shoots two bad guys that break into his hote room to rob him. He fires on them until his (Colt Commander .45) gun is empty. Once empty he ends up having to fight with one of the men who is very large. He uses his gun as a club. He figures he must have missed. Eventually the bad guy falls out. Turns out one of the .45 fmj rounds had severed his Aorta. The guy was dead just didn't know it. You coulddn't hope for much better shot placement.
Handguns kill by shutting down the CNS (brain or spine) or dropping the blood pressure too low to sustain life. It can take awhile for a man to bleed out. Each person has to make up their own mind which they would have more confidence in. Less big bullets or more slightly smaller ones. No matter how you cut it .451 vs. .355 or so is not that big of a difference. And frontal area is what does the damage in a handgun sized round. I just can't help but think if he would of had a 16 round 9mm he would of still been shooting and not wrestling. But as I said each must pick their own poison.
I've decided I want lots of bullets in my handgun. Their is no negative to lots of rounds if you shoot well. As far as choice goes the rest of the world and in 1985 the U.S. Military decided that more rounds was a better choice. If I'm a downed pilot with only a pistol do I want 15-16 rounds with the mag in my pistol? Or do I want 30-31 in my pistol? I know what I would choose.