Anyone who thinks that any small arm can stop any automobile instantly is only fooling themselves. I saw a dash-cam video of a nut trying to run down a LEO by pinning him between his SUV and the front of his cruiser. You see the LEO drop to the ground between the 2 vehicles(looked like he was a goner) and somehow end up on the ground right beside the driver's door of the SUV. He put 8 rounds from his service pistol in the door of that SUV at point-blank range and not a one hit the driver. The deflection is too great to accurately penetrate the door and hit the driver. If you do you got very lucky. Scared him enough to surrender though.
Tires are hard to hit on a vehicle that is moving irradically trying to hit people., The tread is steel belted and hard to penetrate, the sidewalls are easy to penetrate. Popping the tires will slow the vehicle down dramatically and give people an opportunity to run. A laminated windshield is hard to penetrate accurately and if you are shooting at the windshield you're the next victim. The radiator is easy to hit but again if you are shooting at the radiator you're the next victim and the vehicle will continue on for quite some time. If he keeps it moving fast enough he's got a good 30 minutes.
The driver's side window is probably your best bet. It will completely shatter with the first hit. And then you have a clear shot on the driver. But you are still shooting at a fast moving target.
The story about the bullet lodging between the starter and flywheel and stopping the engine is BS. The engine has more than enough power to either munch the bullet or strip a couple teeth off the flywheel.
There are only a couple things you could hit with a bullet that could stop a car instantly. None of them are in the same place in all cars. If it's a newer car you could hit the ECU/computer or a fuel line, both would kill the engine almost instantly. The computer can be almost anywhere. Anywhere in the engine compartment, inside the dashboard, and passenger's side footwell are places that come to mind as the most common. You could hit the fuel lines which are about as big around as a pencil and run along the inside of the framerail so your chances of hitting them are slim and none. The coil or distributor(if it has a distributor, newer cars don't), again they can be just about anywhere in the engine compartment and most are, give or take, the size of a beer can.
Way too much junk between the outside of the car and engine itself to expect to damage it enough to stop it. Just because a particular handgun or rifle can damage an engine doesn't mean it can after going through all the junk it has to to get there.
The nut behind the wheel is still your best target but it's a moving target, somewhat shielded and could be trying to hit you. Find a place you can take good aim from that you are protected from the vehicle and give it a try if you think you can do it. But if you are trying to hit a moving vehicle I find it doubtful that you can fire at it and not break rule #4(Be absolutely sure of your target, and what is behind it).
A few rounds in the windshield may make it really hard for him to see and find victims. Hitting the tires will dramatically slow it down. Killing the driver will stop it the next time it hits something solid at the latest. There are no easy options.