Nearly every single day, a Beretta 21A .22 gets tucked into my front right jeans pocket.
I really want to love carrying either a 1911 Mil-Spec, or a K frame S&W, but when I'm out, moving around the acreage, in and out of tractors, pickups, etc, I find myself getting hung up on a holster, or get tired of one sticking me in the side while driving or doing field work. A good rifle is even more hassle, but would be a better bet, when needed.
I don't always favor the .22 over a .45 or .357, but a little gun beats no gun. The little Bobcat just rides there, in my front jeans pocket. Every day. All the time.