I have largely reverted to .38 and .357 revolvers, SP101 on the small side, to GP100 on the large side, with .38 K-Frames in the middle. I will up-gun to the GP100,with real Magnums, if going where feral hogs, and packs of large feral dogs, are likely threats. People have been killed by both, in this general area, in recent years and months. The lighter .357 revolvers are loaded with milder Magnums, or .38 Specials.
I will opt for my .38 K-Frame snub-guns, when I feel like carrying speed loaders, and/or when I want to use one particular holster, which is suited to specific clothing combinations, or, another specific holster, for similar reason, with other clothing, or, when I simply feel like it. (An SP101 does not have much “work space” available, for speed loader reloading.)
Then, sometimes, there is a special niche, for something like .32 ACP, in a Seecamp LWS-32.
If I anticipate my weapon being at risk of being dunked in water, well, 9mm Glock. Another reason for a 9mm Glock might be when I have to go to a place where “social trouble” is likely, especially at night, when a Surefire X300 might be a desirable accessory. It is not always practical to wait for the cavalry; one might have to be one’s own cavalry,
My first handgun love, from the early Eighties, was the 1911. Now and then, I carry a 1911, loaded with .45 ACP, usually as a second gun, because I just want to do so. (The “first” handgun would usually be one of the above-mentioned revolvers.)
I am old enough to realize that that life is too short to be taken so seriously, all the time. When I feel like it, I will carry a single-action revolver, loaded with .45 Colt, because it is fun. Life should be fun, sometimes.
I have no disagreement with folks who wish to emphasize carrying one gun, all the time, because that is the best way to perform optimally. Well, my right hand does not necessarily fit the same as my left, on some handguns. My “reload” may well be a second gun, positioned for lefty access. My right hand has multiple things wrong with it, as I age, which limits what handguns I can still grip firmly, in my right hand. Then, there is how much recoil my right thumb, hand, and wrist can tolerate. Unless/Until I switch to lefty primary carry, I will not have one best primary gun, or one best load, for all occasions, every day.