When I was a youngster, less tham 70, and worked and had non-job affairs in Denver, I tried to carry as much firepower as practical --usually a 1911. I was very practiced with the .45 and a 6" .357 revolver. The weather influenced where the "practical" was, as well as dress code according to the situation.
With retirement and decreasing mobility nowadays, my "adventurous" activity has decreased to just erranding around Golden and Wheat Ridge, which is a less adventurous environment than Denver. So my routine personal defense firearm now is a pocket-carried hammerless laser-sighted J-frame. On rare winter occasions I may OWB carry a laser-sighted Kahr CW9 under my coat
Incidentally, even before Colorado got concealed carry, it was legal to conceal while engaged in the act of hunting with a valid hunting license. I frequenlty took advantage of that "loophole."
I'm in theoretical agreement with the Marine philosophy of absolute familiarity with the one single weapon, but it really is impractical for civilian life. I started shooting in the early 60s with all kinds of firearms and can pick up any handgun and do a creditable job of making its trajectory intersect with what I want to put a hole in.
Terry, 230RN
ETA It is true that with loss of visual acuity in my right "gun eye" over the years, the laser sights are now necessary for defense shooting practice. For just paper-punching, I have sorta-kinda adjusted to using my off eye on iron sights but using a rife lefhanded is something I have trouble with.