What's available locally?
When choosing a caliber I try to consider what's available in the local gun shops where I'm hunting. In the town where I hunt there's a hunting/fishing "sporting goods" shop owned by a local guide. If something happens to the handloads I brought from home or they're left behind (not impossible, my dad once left his license tags home) what is this shop going to carry?
For certain: .30-30, .30-'06, .270 Win, .308 Win, 12 ga.
Probable: .243 Win, .257 Roberts, 7mm Rem Mag, maybe even .25-'06, .35 Rem, and .45-70.
Maybe even some of the Win mag's (.300 Win Mag and .300 WSM come to mind).
So before you bring that 7mm-'08, that .260 Rem, the short action ultra mag, the WSSM, or the foreign surplus rifle. STOP. THINK. Can I find that ammo in the middle of nowhere when the only place that sells ammo is the bait and tackle concession in the local gas station?
BTW my caliber of choice is .30-'06.