.25-06 is seriously overbore, and really needs a 26" tube to be efficient. When you combine that with a long action, is really not a comparable rig to the rifles in the .308 family. 7mm-08 is a great cartirige, but is a handicap from an ammo variety standpoint for the non-handloaders like me.
If you want a handi, compact deer getter, then it is hard to fault any of the .308 family. None require a tube longer than 22" to be effective, all have actions 1/2" shorter than the long actions, and all will take most NA game cleanly. The .243 & .308 clearly provide more variety of ammo on the shelf, so everyone should have one of each.
I have heard that Innuits use the .243 nearly exclusively, and they have kodiac & polar bears to deal with.