Consider the fact that if you have to use your gun to kill someone the gun will be taken by the police as evidence and you may never get it back. Do you REALLY want to use a gun that cost you $400, $700, $1,200 or $2,000?
And a suppressor? Unless it's integral with the barrel, it's going to add significant length to your short barreled gun.
You might consider the High-Point carbine that can be had in 380 Auto, 9mm Luger, 40 S&W and 45 ACP. They may be low end but they're pretty well built and a 10 round magazine is probably enough for a home defense situation.