After all has been said, my 30+ as an LEO years of wiping bad guys off the floor, attending more autopsies than I care to recall, I will repeat what I have said many times before. It doesn't matter what you use for HD purposes.
My 20 gauge Nova has #6 shot in it that I bought from Walmart. I am quite comfortable knowing that it will "take care of business" should the need arise. I have investigated more shootings with small shot than buckshot. At HD distances, either of them will take down a bad guy if he is hit in the vitals, no matter how many clothes and coats he has on. If he is not hit in the vitals, a 50 cal machine gun won't stop him if he is determined to go on.
We had a firefight when I first started in LE. My buddy got hit in the abdomen with a load of 00 buck. It took out a kidney and he was out of work for a year. He lived to retire. The bad guy got taken down with a 30 cal M-1 carbine, the issue rifle of the time.
I will repeat it for what it is worth: It doesn't matter what you have in your musket. If you have a home invasion, burglary, or the need to take down a bad guy, just put it in the vitals. If a refrigerator is in your way, shoot some more. Keep shooting until the menace is down.
My respects to everyone that disagrees with me. I have been there, done that. Most folks have been lucky enough not to observe the sad incidents I have seen. One or two investigations does not make a certain load better than another. Cumulative years and decades of wiping these creeps off the floor and streets tell me that for HD, it doesn't matter. Just use what you have in the chamber. It will work.