What a terrible thought! But if I had to choose...
22-250 for prairie dogs-Coyotes
6.5-300 Weatherby for hunting antelope-deer and long range fun.
308 Win for HD/battle rifle
338 Lapua for longer range work for elk size game through moose
460 Weatherby will kill anything else on the planet
Honorable mentions: 6.8 SPC, didn't make the list because my 308s fill roughly the same role for my purposes. 300 win mag, not enough advantage over the 6.5 -300 weatherby, and 338 lapua can be downloaded and/or put in a hunting rifle. 45/70...had a hard time leaving this one out because I love lever guns, but would be more comfortable against large dangerous game with a 460 weatherby and it can be downloaded as well. 556. For the same reason as 6.8 spc...would just rather have 308, and for hunting the 22-250 thumps harder and faster.
The irony is I only own 3 of the 5 finalists, but have all the honorable mentions.
...maybe its time to add a couple to the stable.