I'm a 70 year old revolver lover, with a bit of arthritus and carpel tunnel myself. I've searched high and low for a carry gun all my life, mostly I admit because I like trying new guns, but there is a little bit of "I can't find one I really like" in there too. I've tried dozens of revolvers, small 9mm's, even the Smith and Wesson EZ...couldn't stand them for some reason. I just didn't like them, 9mm or 380.
Well, I've finally found the one I'm going to keep and use. Actually I have two, but only one of them gets used regularly. The winner is a Beretta 84F, in 380. A conventional DA/SA with a 13 round magazine, + 1 in the chamber of course. It has a manual safety/decocker, which can be just left in the "off" position and carried depending on the long D/A trigger as a practical safety. Speaking of the safety/decocker, when used to decock, it sets the hammer in a half-cock position, making the DA first shot, shorter and lighter by at least half. It's not a small gun, with a 4" barrel and a full sized double stack grip it spreads the recoil out quite well, making it very plesant to shoot. Magazine release is in the conventional "American" position.
Now the down side. The sights are very small, and I suppose if one had vision problems, they might be a problem. The front sight is part of the slide so it can't practically be changed. I don't have any problems with them but I do limit my range time to the 5-7 yard distance mostly. They're also currently out of production, so the used market is the only real source, and they can be somewhat expensive in the $600 range. As an aside, they are also available in 32 ACP, although I personally have never seen one I don't think.
However, as so often happens, nature abhores a vacuum. Tisas of Turkey makes a "clone" of the Model 84, called a Fatih 13, that is currently available. It's a clone of the Model 84BB, so it lacks the decocker/safety the F model has, meaning you have to either carry it cocked and locked, or manually lower the hammer on a live round, something I have no problem doing, but perhaps someone with more severe arthritus may not be comfortable with. The Tisas also sells for about half what a Beretta will likely set you back. Both guns have been flawless with both FMJ and HP ammo for me, with the Tisas drawing EDC duties, simply because I don't want to mess up the Beretta. I'd rather bang plastic grips off furniture, cars and such than wood ones.
With both guns, you can carry with the safety "on" if you want to, I just choose to depend of the DA trigger, which by the way is quite nice on both, as is the SA. Physically, they're about the size of a Shield, a little smaller than a Glock 19 type gun. I carry them in a Maxx Carry, IWB holster. Even fully loaded, they're not really heavy. They not LCR light, but I don't notice them. Magazines are interchangable.
A lot of people say they're hard to rack the slide. I thought so at first, but have developed a technique that works for me, gripping the slide by the front scallop and pulling/push from there, not the rear of the slide. Keep your hand behind the muzzle, and your finger off the tirgger, and no problem. I also have a little gizmo called a Pachmayr Slide assist tool (or something like that) that is a godsend when racking a slide, but probably not practical for EDC use. At the range, or at home, though it's great.
https://www.midwayusa.com/product/1018761599/
Those are my thoughts, sort of an old school solution. Probably not for everyone, but this old man really likes them.