I don't put a lot of faith in the "bigger holes = better stopping" idea. The human body can move and function quite a long time with severe trauma to vital areas. The bloodstream has enough oxygen in it for the brain to keep working for more than 30 seconds even if the heart is gone. Same with the lungs. Stomach, intestine, kidney, etc are all painful shots but don't do anything to incapacitate body movement. And even causing severe bleed-out still leaves enough oxygen enriched blood getting to nerve centers to allow the subject some form of movement from anywhere from several seconds to even minutes. If that movement involves pulling a trigger in your direction...you haven't really done much to save your life.
Nerve center hits are the only true way to stop a threat immediately. The CNS (spinal cord, brain stem, and brain) all control movement and bodily functions. Only damaging those nerves can actually stop motion (short of severing the limb/muscle in question). I pick my caliber and weight that gives me the most chances of getting a bullet through the body, and into a nerve group like the brain or spinal cord. Everything else is fluff. A big .45 caliber wound to the stomach isn't going to stop a bad guy from flexing his trigger finger. A round of any sort that makes it to the spinal cord and causes enough damage on the other hand, will. So again, I pick the round that gives me the most chances of doing exactly that. Four 9mm shots, where 3 are mediocre but one severs the spinal cord, are far better than bigger bullets causing messy wounds but not truly incapacitating the target. IMO, more chances to hit the CNS trumps fewer chances that make messier holes.
Ever wonder why we aim for center mass and not slightly offset at the heart? CNS shots. Always shoot for the CNS. Everyone always says that shot placement trumps caliber. And they're right. Ask yourself, which caliber has the lightest recoil, and thus gives me a better chance for accurate followup shots? Which caliber gives me the most chances as good followup shots? If one truly believe shot placement is more important that caliber, one should pick a round that gives them the most and best chances at accurate shot placement, and not the one that gives you fewer chances to make a big messy hole.