I'll admit, I'm not reading all 4 pages of comments, but this is my take;
Comfort is relative. If you are thrilled to death with the notion of being able to carry, you will think that a full-size Desert Eagle in your waistband is the greatest thing in the world. (Don't laugh, I know a few people who, well, never mind.) If you have never had to carry anything on your person larger than a cell phone, you will think a sub-compact Glock is like a horrible tumor you are forced to live with.
I carry a full-size 1911. (Kimber Custom II.) There are a couple of reasons for this. I have been trained that the mission is first, comfort isn't even second. You carry the best weapon for the job. A full-size pistol has the best sight radius, increasing accuracy. Full-size pistols are usually heavier, and more controllable in combat fire. I for one would not want to sacrifice accuracy for a shorter frame that feels only a little lighter and easier in the waistband. You still know there's a gun there. Mission first.
The other thing that could just be my own stinginess, is I hate the idea that I have to run out and buy every new gun that I didn't know I needed until I read it in G&A. "Great carry gun!! World's best combat 1911! (Like we soldiers get to choose what pistol we carry to war in the first place,) All new world-class competion 1911!" I want to get the best all around pistol for everything. I don't want to jump up and re-tool all of my rigs every time 1911s change color. One good 1911, night sights, flat finish, .22 conversion kit, a few different holsters. If I'm using it for hunting, competing, plinking, or defending my life, I have the same setup for everything.