For me, natural pointer sidearms means drawing quickly with precision shooting on a moving target, while I am moving. In most cases, there isn't time to line up sights or I'm in a low light situation.
I've always known that 1911s were excellent pointers after training, qualifying and carrying one. Years later I learned how good 1911s can be when needed.
The 38 Super has become one of my favorite pistols while out and about on the property. My wife didn't notice this rattler while we were walking together, had her look for #2 rattler, good practice to look for a second rattler upon seeing a rattler, as I held her hand walked left. Guesstimated where it's heart was and fired, one hit stop;
Another encounter after sunset, taking the dog out after returning home from town. I was still carrying a Browning Hi-Power when this Mojave coiled back to strike as I moved toward it to close the distance. Unable to see its head, focused on the top of the recoil, very downward angle hit behind the head and gut shot it.
In the below pic is another Mojave rattler in a clump of grass, it had double struck a Bassett that was staying with me;
I have learned that CCI snakeshot in 357mag does not kill rattlesnakes, M686 P 6" and a single 125gr Remington SJHP ended this threat once and for all;
This is the only rattler head I have recovered.
These are my top three platforms for natural pointers and they have been used a number of times, including fast charging pit bulls.
I carry 1911s in 38-super, 10mm and 45auto; plus the 357mag are major calibers that can take down 4 legged critters up to and including black bears.