I'll probably ruffle a few feathers, but what the hey.
In a revolver that weighs less than 40 ounces, all full-power .357 loadings are overkill...and mostly on the back end. The possible exception is the 110-grain loadings, and those typically generate less velocity than the 125-grain Hammers of Thor.
Conventionally accepted wisdom states that hitting an attacker twice doubles the odds of putting him down. i.e. rapid multiple hits are better than one hit, regardless of power level.
Back when Marshal and Sanow first published their book, Jeff Cooper was questioned about their findings that .45 hardball only rated 65% in one-shot effectiveness. In typical Cooper fashion, he shrugged and responded. "Shoot twice."
Being possessed of large, strong hands and a pretty hefty grip, I have trouble enough controlling a 3-inch Model 13 with full power .357 ammunition with any bullet weight well enough to make good, rapid followup hits at much more than about 15 feet. I haven't even attempted it with any of the new "superlite" class of .357 revolvers because it would probably be a waste of time and ammunition.
And I know that everybody envisions the proverbial rock-solid grip and this or that ideal stance in that awful, suspended moment of truth...but the reality is that these things have a way of going to hell in a handbasket in the blink of an eye.
My 2% of a buck.